Read
Seeing chromatin
(ORCA & spatial imaging)
- Single-cell 3D chromatin tracing and multimodal DNA·RNA·protein imaging
Read Reason · Rewrite Chromatin
Reading the grammar of chromatin regulation — and learning to rewrite it — to build the next generation of gene and epigenome engineering tools.
크로마틴 해독·설계 연구실
About the lab
Reading the rules of chromatin regulation — and rewriting them
Chromatin — its 3D folding and its epigenetic state — sets the rules of gene regulation. CODE Lab works to read those rules and rewrite them. We observe chromatin organization directly, in single cells, to understand how 3D structure and epigenetic modifications control gene expression, and we turn that understanding into precise, programmable tools for genome and epigenome control. Discovery is led by ORCA-based multimodal spatial imaging of DNA, RNA, and protein, complemented by bottom-up synthetic biology that rebuilds regulatory logic from minimal parts.
Read
What is chromatin actually doing?We observe chromatin where it acts, in single cells. Our flagship is ORCA-based multimodal spatial imaging of DNA, RNA, and protein in the same cell — backed by spatial transcriptomics, flow cytometry, qPCR, Western blotting, nanopore and next-generation sequencing.
Reason
What rules explain it?Using bottom-up synthetic biology, we rebuild epigenetic regulation from minimal parts to find the principles — the read–write logic and memory — sufficient to explain it, supported by computational modeling.
Rewrite
Can we program it?We build what the rules predict: programmable genome- and epigenome-engineering tools for precise, durable control of gene expression — toward new therapeutic strategies.
Research
Three ways we read and rewrite chromatin
Seeing chromatin
Reason
Decoding the rules (synthetic biology)
- Bottom-up circuits and minimal mechanistic rules sufficient for regulation
Rewrite
Engineering genomes & epigenomes
- Programmable tools for precise gene and epigenome control
Join us
Come read, reason, and rewrite with us
We are looking for highly motivated and collegial graduate students, postdocs, and undergraduate researchers excited about chromatin, gene regulation, imaging, synthetic biology, epigenome engineering, and computational work.
Tell us what you want to read and rewrite.
Interested applicants should send a CV and a summary of previous research (or research interest) to Prof. Minhee Park at minheepark at kaist dot ac dot kr.